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Butyrolactone I
Item number: BVT-0448-C200
White to off-white solid. Soluble in DMSO, methanol, ethanol or acetone. Isolated from Aspergillus terreus. Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to...
| Application: | Cell permeable CDK-1, -2, -5 inhibitor, Apoptosis inducer |
| CAS | 87414-49-1 |
| MW: | 424.5 D |
From 100.00€
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Butyrolactone I
Item number: Cay21765-1
Butyrolactone I is a secondary metabolite from A. terreus that acts as an ATP-competitive inhibitor of cyclin-dependent kinase 1 (Cdk1, IC50 = 20 µg/ml in PC-14 cells). It induces dose-dependent G2/M arrest, inhibits DNA synthesis, and decreases Cdk1 protein expression in vitro. Butyrolactone I has antitumor effects...
| Keywords: | (2R)-2,5-dihydro-4-hydroxy-2-[[4-hydroxy-3-(3-methyl-2-buten-1-yl)phenyl]methyl]-3-(4-hydroxyphenyl)-5-oxo-2-furancarboxyl... |
| Application: | Cdk1 inhibitor |
| CAS | 87414-49-1 |
| MW: | 424.5 D |
From 249.00€
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