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Item number: Cay15149-1

Cyclin-dependent kinase 1 (Cdk1) complexes with different cyclins, with the cyclin determining substrate specificity. Ro 3306 is a cell-permeable, reversible inhibitor of Cdk1, showing preference for Cdk1/cyclin B1 (Ki = 35 nM) over Cdk1/cyclin A (Ki = 110 nM), two CDK complexes which regulate cell cycling. It also...

Keywords:	5Z-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone
Application:	CDK1 inhibitor
CAS	872573-93-8
MW:	351.4 D

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RO-3306

Item number: AG-CR1-3515-M005

Selective CDK 1 inhibitor (Cdk1/B1 and Cdk1/A). Potential anti-cancer compound. Cell cycle arrest inducer at G1, S and G2/M. Apoptosis inducer in embryonic stem cells. Actively enhances downstream p53 signaling to promote apoptosis in AML cell lines. Suppresses phosphorylation of p53 at Ser315 and procaspase-8 at...

Keywords:	(5Z)-2-((Thiophen-2-yl)methylamino)-5-((quinolin-6-yl)methylene)thiazol-4(5H)-one
Application:	CDK1 inhibitor, Apoptosis inducer
CAS	872573-93-8
MW:	351,5 D

From 33.00€ *

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