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Item number: TGM-T3965-100mg

Description: Fevipiprant (NVP-QAW039) is a selective, potent, reversible competitive CRTh2 antagonist. Target: GPR, Prostaglandin Receptor. Smiles: Cc1c(CC(O)=O)c2cccnc2n1Cc1ccc(cc1C(F)(F)F)S(C)(=O)=O. References: Sykes DA, et al. Fevipiprant (QAW039), a Slowly Dissociating CRTh2 Antagonist with the Potential for...

Keywords:	QAW039, NVP-QAW039
Application:	Targets prostaglandin D2 receptor (PTGDR)
CAS	872365-14-5
MW:	426.41 D

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Fevipiprant

Item number: Cay20263-1

Fevipiprant is a DP2/CRTH2 antagonist (Ki = 1.05 nM). It reduces shape change of eosinophils induced by prostaglandin D2 (PGD2, Cay-12010) with IC50 values of 0.4 and 0.44 nM for isolated human eosinophils and human whole blood, respectively. Fevipiprant inhibits PGD2-induced release of IL-5 and IL-13 in isolated...

Keywords:	NVP-QAW039, QAW039, 2-methyl-1-[[4-(methylsulfonyl)-2-(trifluoromethyl)phenyl]methyl]-1 H -pyrrolo[2,3b]pyridine-3-acetic...
Application:	Prostaglandin D2 receptor antagonist
CAS	872365-14-5
MW:	426.4 D

From 78.00€ *

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