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Item number: Cay42535-1

Dipraglurant is a negative allosteric modulator (NAM) of metabotropic glutamate receptor 5 (mGluR5, Ki = 21 nM). It inhibits glutamate-induced calcium mobilization, inositol monophosphate (IP1) accumulation, and ERK1/2 phosphorylation in HEK293A cells expressing rat mGluR5a (pKBs = 5. 6. and 6. respectively)....

Keywords:	ADX-48621, 6-fluoro-2-[4-(2-pyridinyl)-3-butyn-1-yl]-imidazo[1,2-a]pyridine
Application:	MGluR5 negative allosteric modulator
CAS	872363-17-2
MW:	265.29 D

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Dipraglurant

Item number: TGM-T15134-100mg

Description: Dipraglurant (ADX48621) is a negative alteration modulator (NAM) of mGluR5 that inhibits dyskinesia in the LID macaque model. Target: GluR. Smiles: Fc1ccc2nc(CCC#Cc3ccccn3)cn2c1. References: Bezard E, et al. The mGluR5 negative allosteric modulator dipraglurant reduces dyskinesia in the MPTP macaque...

Keywords:	ADX48621
CAS	872363-17-2
MW:	265.29 D

From 93.00€ *

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