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Item number: TGM-T14076-1mg

Description: A-839977 is a selective P2X7 receptor antagonist with anti-inflammatory and analgesic properties, inhibiting BzATP-induced calcium efflux from the P2X7 receptor, and is used in the study of renal fibrosis. Target: P2X Receptor, Calcium Channel. Smiles: Clc1cccc(c1Cl)-n1nnnc1NCc1ccccc1Oc1ccccn1....

Keywords:	A-839977, A839977
Application:	P2X7 receptor antagonist
CAS	870061-27-1
MW:	413.26 D

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A-839977

Item number: Cay30934-1

A-389977 is an antagonist of the purinergic P2X7 receptor. It inhibits BzATP-evoked intracellular calcium influx in 1321N1 cells expressing human, rat, and mouse receptors (IC50s = 20, 42, and 150 nM, respectively). A-839977 inhibits BzATP-induced YO-PRO dye uptake, a marker of membrane pore formation, and IL-1beta...

Keywords:	1-(2,3-dichlorophenyl)-N-[[2-(2-pyridinyloxy)phenyl]methyl]-1H-tetrazol-5-amine
Application:	P2X7 receptor antagonist
CAS	870061-27-1
MW:	413.3 D

From 44.00€ *

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