Thiolutin is a natural dithiol that reversibly inhibits bacterial and yeast RNA polymerases (IC50 = 3 µg/ml). Because of this, it can be used for the analysis of mRNA stability. Thiolutin also inhibits endothelial cell adhesion (IC50 induced angiogenesis in mice by inhibiting Hsp27 interactions with cytoskeletal...

A sulfur containing antibiotic which is a potent inhibitor of RNA polmerase. Inhibits adhesion of human umbilical vein endothelial cells and thereby suppresses tumor cell induced angiogenesis.

Description: Thiolutin (Acetopyrrothin) is an inhibitor of endothelial cell adhesion and produced by Streptomyces. Thiolutin shows antibiotic and anti-angiogenic properties. Thiolutin induces the phosphorylation of Hsp27 rapidly. Target: Antibacterial, Antibiotic. Smiles: CC(=O)Nc1c2sscc2n(C)c1=O. References:...

Thiolutin is an antibiotic first described by Tanner and co-workers in 1950. Resurgent interest in this class of microbial metabolite was stimulated by the discovery of their selective antitumor activity. Thiolutin has been shown to be a potent inhibitor of bacterial and yeast RNA polymerases and inhibitor of mannan...