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IN 1130
Item number: Cay43285-10
IN 1130 is an inhibitor of activin receptor-like kinase 5 (ALK5), also known as TGF-beta receptor type 1 (TGF-betaRI, IC50 = 5. nM). It is selective for ALK5 over a panel of 27 other kinases at 5 µM. IN 1130 (10 mg/kg per day) decreases renal fibrogenesis, inflammatory cell infiltration, and tubular atrophy in a...
| Keywords: | 3-[[5-(6-methyl-2-pyridinyl)-4-(6-quinoxalinyl)-1H-imidazol-2-yl]methyl]-benzamide |
| Application: | ALK5 inhibitor |
| CAS | 868612-83-3 |
| MW: | 420.48 D |
From 147.00€
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IN-1130
Item number: TGM-T15572-100mg
Description: IN-1130 is a selective inhibitor of ALK5 with IC50 values of 5.3 nM, 36 nM, and 4.3 µM for phosphorylation of ALK5-mediated Smad3, ALK5 phosphorylation of casein and p38alpha mitogen-activated protein kinase. Target: ALK. Smiles: Cc1cccc(n1)-c1nc(Cc2cccc(c2)C(N)=O)[nH]c1-c1ccc2nccnc2c1. References: Moon...
| CAS | 868612-83-3 |
| MW: | 420.47 D |
From 46.00€
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