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Item number: TGM-T16703-100mg

Description: Quarfloxin (CX-3543) is a fluoroquinolone derivative with antineoplastic activity with IC50 values in the nanomolar range in neuroblastoma cells. Quarfloxin disrupts the interaction between the nucleolin protein and a G-quadruplex DNA structure in the ribosomal DNA template. Target: DNA/RNA Synthesis....

Keywords:	CX-3543
Application:	Targets DNA topoisomerase II [EC:5.6.2.2] (TOP2)
CAS	865311-47-3
MW:	604.67 D

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Quarfloxin

Item number: Cay36552-1

Quarfloxin is an inhibitor of RNA polymerase I-mediated transcription. It binds to G-quadruplex DNA and inhibits the interaction between ribosomal DNA G-quadruplexes and nucleolin, a nucleolar protein required for RNA polymerase I-mediated transcription. Quarfloxin (10 µM) induces nucleolin mislocalization from the...

Keywords:	CX-3543, Itarnafloxin, Quarfloxacin,...
Application:	RNA polymerase I-mediated transcription inhibitor, antineoplastic, topoisomerase II inhibitor
CAS	865311-47-3
MW:	604.7 D

From 83.00€ *

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