Description: Epoxy Fluor 7, a fluorescent substrate specific to soluble epoxide hydrolase (sEH), is utilized in the measurement of sEH activity through its hydrolysis-induced fluorescence in both human and mouse enzymes. Smiles: C(OC(OC(C#N)C1=CC2=C(C=C1)C=C(OC)C=C2)=O)[C@H]3[C@@H](O3)C4=CC=CC=C4

Soluble epoxide hydrolase (sEH) catalyzes the conversion of epoxyeicosatrienoic acids (EpETrEs) to the corresponding DiHETrEs thereby diminishing their vasodilator activity. Inhibitors of sEH may therefore have clinical utility for treating hypertension and systemic inflammation. Epoxy fluor 7 is a sensitive...