Description: Ethotoin (Peganone), an orally active anticonvulsant agent utilized in epilepsy research, is a hydantoin derivative analogous to phenytoin [1]. Target: Others. Smiles: CCN1C(=O)NC(C1=O)C1=CC=CC=C1

Ethotoin is a hydantoin anticonvulsant. It shortens the duration of the tonic extensor aspect of seizures induced by maximal electroshock in rats when administered at doses ranging from 500-1,000 mg/kg. It also decreases the duration of the tonic phase of seizures at a dose of 1,000 mg/kg but does not affect the...