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Item number: Cay24085-1

Linaclotide is a peptide agonist of the guanylate cyclase C receptor (Ki = 16.4 nM in a radioligand binding assay using mouse intestinal mucosa). Luminal exposure to 5 µg of linaclotide stimulates fluid secretion and cGMP concentration in jejunal loops isolated from wild-type mice but not guanylate cyclase C...

Keywords:	L-cysteinyl-L-cysteinyl-L-alpha-glutamyl-L-tyrosyl-L-cysteinyl-L-cysteinyl-L-asparaginyl-L-prolyl-L-alanyl-L-cysteinyl-L-t...
Application:	Guanylate cyclase C receptor / enterotoxin receptor agonist
CAS	851199-59-2
MW:	1526.7 D

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Linaclotide

Item number: TGM-T11852-100mg

Description: Linaclotide, developed for the treatment of constipation-predominant irritable bowel syndrome (IBS-C) and chronic constipation, is a potent and selective guanylate cyclase C agonist. Target: Guanylate cyclase. Smiles:...

Application:	Targets heat-stable enterotoxin receptor [EC:4.6.1.2] (GUCY2C)
CAS	851199-59-2
MW:	1526.74 D

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