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Item number: Cay22128-1

SSR 128129E is a potent inhibitor of the FGF receptor (FGFR, IC50 = 1.9 nM). It reduces FGF2-induced endothelial cell proliferation and migration (IC50s = 31 and 15.2 nM, respectively), as well as lamellipodia formation in vitro. SSR 128129E also reduces proliferation of PAE cells expressing FGFR1, mPanc02 cells...

Keywords:	2-amino-5-[(1-methoxy-2-methyl-3-indolizinyl)carbonyl]-benzoic acid, monosodium salt
Application:	FGFR Inhibitor
CAS	848318-25-2
MW:	346.3 D

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SSR128129E

Item number: TGM-T6082-100mg

Description: SSR128129E (SSR) is an allosteric and orally-active FGFR1 inhibitor (IC50: 1.9 µM), but not affecting other related RTKs. Target: FGFR. Smiles: [Na+].COc1c(C)c(C(=O)c2ccc(N)c(c2)C([O-])=O)n2ccccc12. References: Bono F, et al. Cancer Cell. 2013, 23(4), 477-488.

Keywords:	SSR
Application:	FGFR Inhibitor
CAS	848318-25-2
MW:	346.31 D

From 33.00€ *

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