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Item number: Cay27651-1

Varlitinib is an inhibitor of EGFR and HER2 (IC50s = 7 and 2 nM, respectively). It inhibits cell proliferation (IC50s = In vivo, varlitinib (100 mg/kg) inhibits phosphorylation of EGFR and ERK and reduces tumor weight in an MDA-MB-468 mouse xenograft model.Formal Name:...

Keywords:	ARRY-334543, N4-[3-chloro-4-(2-thiazolylmethoxy)phenyl]-N6-[(4R)-4,5-dihydro-4-methyl-2-oxazolyl]-4,6-quinazolinediamine
Application:	EGFR / HER2 inhibitor
CAS	845272-21-1
MW:	466.9 D

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