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R406
Item number: Cay11422-1
R406 is a potent ATP-competitive inhibitor of spleen tyrosine kinase (Syk, Ki = 30 nM). Through this action, R406 blocks FcepsilonRI-dependent mast cell activation (EC50 = 43 nM) and, at 3 µM, reduces the release of IL-10, -12, and -13 by immune complex-pulsed dendritic cells. R406 is orally available and can reduce...
| Keywords: | 6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one |
| Application: | Potent ATP-competitive Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470.5 D |
From 92.00€
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R406
Item number: SYN-1121-M001
Soluble in DMSO or ethanol. R406 is a strong Syk inhibitor with an IC(50) of 41nM. It inhibits Syk but not Lyn. It shows 5-fold less potency to Flt3. Target: Syk , Kinase Group: PTK , Substrate: Tyrosine
| Keywords: | R-406 |
| Application: | Syk inhibitor |
| CAS | 841290-80-0 |
| MW: | 470,5 D |
From 132.00€
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