Description: Syrosingopine has selective depleting effect on brain amines is potentiated by combined treatment with disulfiram or fusaric acid, a dopamine beta-hydroxylase inhibitor. Target: Dopamine Receptor. Smiles:...

Syrosingopine is an inhibitor of monocarboxylate transporter 1 (MCT1) and MCT4 (IC50s = 2,500 and 40 nM, respectively). It inhibits MCT-facilitated lactate export and decreases intracellular pH in HL-60 promyeloblast cells when used at a concentration of 10 µM. Syrosingopine (5 µM), in combination with metformin...