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Item number: Cay18387-1

Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...

Keywords:	PHA-739358,...
Application:	Aurora kinase inhibitor
CAS	827318-97-8
MW:	474.6 D

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Danusertib

Item number: SYN-1095-M001

Soluble in DMSO or ethanol. Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid...

Keywords:	PHA-739358
Application:	Aurora inhibitor
CAS	827318-97-8
MW:	474,6 D

From 139.00€ *

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