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Danusertib
Item number: Cay18387-1
Danusertib is a pan-Aurora kinase inhibitor (IC50s = 13, 79, and 61 nM for Aurora A, B, and C, respectively) that also targets Abl, Ret, TrkA and FGFR1 (IC50s = 25, 31, 31, and 47 nM, respectively). It exhibits anti-proliferative and pro-apoptotic activity against a panel of cancer cells in vitro, including those...
| Keywords: | PHA-739358,... |
| Application: | Aurora kinase inhibitor |
| CAS | 827318-97-8 |
| MW: | 474.6 D |
From 57.00€
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Danusertib
Item number: SYN-1095-M001
Soluble in DMSO or ethanol. Aurora kinases are key regulators of protein phosphorylation during mitosis, and these serine/threonine kinases interact with other cellular proteins to help control chromosome assembly and segregation during mitosis. Aurora kinases are often highly expressed in malignancies and solid...
| Keywords: | PHA-739358 |
| Application: | Aurora inhibitor |
| CAS | 827318-97-8 |
| MW: | 474,6 D |
From 162.00€
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Danusertib
Item number: TGM-T2094-100mg
Description: Danusertib (PHA-739358) is a small-molecule 3-aminopyrazole derivative with potential antineoplastic activity. Danusertib binds to and inhibits the Aurora kinases, which may result in cell growth arrest and apoptosis in tumor cells in which Aurora kinases are overexpressed. Target: Trk receptor, Aurora...
| Keywords: | PHA-739358 |
| CAS | 827318-97-8 |
| MW: | 474.55 D |
From 46.00€
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