Ganciclovir is an active metabolite of the prodrug valganciclovir (Cay-13875) and an antiviral nucleoside derivative of 2'-deoxyguanosine (Cay-9002864). It reduces human, monkey, mouse, and guinea pig CMV replication in plaque reduction assays (EC50s = 1.3-70 µM). Topical application of ganciclovir (0.15%) decreases...

A nucleoside analog used to disrupt DNA replication. It shows antitumor activity when used in combination with HSV1-tk gene transfection.

Ganciclovir (GCV) is a pro-drug nucleoside analog that is activated by phosphorylation. It is useful in the study of gene therapy in cancer research. Upon expression of a viral suicide gene encoding thymidine kinase, the non-toxic pro-drug is converted to a phosphorylated active analog and is incorporated into the...

Description: Ganciclovir (2'-Nor-2'-deoxyguanosine) is an ACYCLOVIR analog that is a potent inhibitor of the Herpesvirus family including cytomegalovirus. Ganciclovir is used to treat complications from AIDS-associated cytomegalovirus infections. Target: Antibiotic, Antifection, Nucleoside Antimetabolite/Analog,...

White to light yellow powder. Soluble in 0.1 N HCl (10mg/ml). Slightly soluble in DMSO (1mg/ml). Chemical. CAS: 82410-32-0. Formula: C9H13N5O4. MW: 255.23. Ganciclovir is antiviral synthetic analog of the nucleoside 2'-deoxy-guanosine, which is used to treat or prevent cytomegalovirus (CMV) infections. It acts as a...