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Item number: Cay23489-1

Vesnarinone is an inhibitor of phosphodiesterase 3 (PDE3, IC50s = 10.7 and 13.2 µM for PDE3A and PDE3B, respectively). It also inhibits ether-a-go-go-related gene 1 (ERG1) channels (IC50 = 1.1 µM in HEK293T cells expressing human ERG1). Vesnarinone (3-300 µM) increases contractile tension in isolated ventricular...

Keywords:	OPC 8212, 6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydro-2(1H)-quinolinone
Application:	PDE3 inhibitor
CAS	81840-15-5
MW:	395.5 D

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Vesnarinone

Item number: TGM-T3465-100mg

Description: Vesnarinone (Arkin) (INN) is a mixed phosphodiesterase 3 inhibitor and ion-channel modifier that has modest, dose-dependent, positive inotropic activity, but minimal negative chronotropic activity. It also suppresses cell proliferation and induces apoptosis by inducing the expression of p21, an...

Keywords:	OPC-8212 , Arkin , Piteranometozine
Application:	Cardiotonic, Phosphodiesterase inhibitor
CAS	81840-15-5
MW:	395.45 D

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