Description: Nodinitib-1 (CID-1088438) is a potent and selective NOD1 inhibitor with an IC50 of 0.56 µM. Target: NOD, NOD-like Receptor (NLR), TNF. Smiles: Cc1ccc(cc1)S(=O)(=O)n1c(N)nc2ccccc12. References: Khan PM et al. ACS Med Chem Lett, 2011, 2(10), 780-785.

NOD1 is a member of the NACHT and leucine-rich repeat domain-containing proteins (NLR) family of innate immunity proteins. It recognizes distinct molecular patterns from bacterial ligands and activates NF-kappaB, stress kinases, and interferon response factors important for host defense and inflammation. Hereditary...