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Mofezolac
Item number: Cay34102-10
Mofezolac is an inhibitor of COX-1 (IC50 = 14 nM). It is selective for COX-1 over COX-2 (IC50 = 440 nM). Mofezolac (1 µg/ml) protects against LPS-induced cell death in BV-2 microglia. In vivo, mofezolac (6 mg/kg, i.p.) reduces hippocampal microglial activation and prostaglandin E2 (PGE2, Cay-14010) production in a...
| Keywords: | N-22, 3,4-bis(4-methoxyphenyl)-5-isoxazoleacetic acid |
| Application: | COX-1 inhibitor |
| CAS | 78967-07-4 |
| MW: | 339.3 D |
From 67.00€
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Mofezolac
Item number: TGM-T5460-100mg
Description: Mofezolac (formerly known as Disopain or N-22) is a highly selective COX-1 (cyclooxygenase-1) inhibitor with COXs selectivity index > 6000. Target: COX. Smiles: COc1ccc(cc1)-c1noc(CC(O)=O)c1-c1ccc(OC)cc1. References: Calvello R, et al.Highly Selective Cyclooxygenase-1 Inhibitors P6 and Mofezolac...
| Application: | Targets prostaglandin-endoperoxide synthase 1 [EC:1.14.99.1] (PTGS1, COX1) |
| CAS | 78967-07-4 |
| MW: | 339.34 D |
From 32.00€
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