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Item number: TGM-T0431-100mg

Description: PCI-24781 (Abexinostat (PCI24781)) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than 40-fold selectivity against HDAC8. Phase 1/2. Target: HDAC. Smiles: CN(C)Cc1c(oc2ccccc12)C(=O)NCCOc1ccc(cc1)C(=O)NO. References:...

Keywords:	CRA 24781, PCI24781, PCI-24781, CRA 024781, PCI 24781
CAS	783355-60-2
MW:	397.42 D

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PCI 24781

Item number: Cay20059-1

PCI 24781 is an HDAC inhibitor that predominantly targets HDAC1 with a Ki value of 7 nM. It inhibits HDAC2, HDAC3/SMRT, HDAC6, HDAC8, and HDAC10 with Ki values of 19, 8.2, 17, 280, and 24 nM, respectively. PCI 24781 can prevent the growth of tumor cells in vitro, inducing apoptosis, as well as in mice harboring...

Keywords:	CRA-024781, CRA-24781, 3-[(dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamide
Application:	Antineoplastic, HDAC inhibitor
CAS	783355-60-2
MW:	397.4 D

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