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Begacestat
Item number: Cay27916-1
Begacestat is an inhibitor of gamma-secretase that inhibits cleavage of amyloid precursor protein (APP) to amyloid-beta (1-40) (Abeta40, Cay-21617) in vitro (IC50 = 15 nM). It is 14-fold selective for gamma-secretase over Notch-1. Begacestat (5 mg/kg) reduces brain levels of Abeta40 and Abeta42 (Cay-20574) in the...
| Keywords: | GSI-953, 5-chloro-N-[(1S)-3,3,3-trifluoro-1-(hydroxymethyl)-2-(trifluoromethyl)propyl]-2-thiophenesulfonamide |
| Application: | gamma-secretase inhibitor |
| CAS | 769169-27-9 |
| MW: | 391.7 D |
From 84.00€
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Begacestat
Item number: TGM-T14525-2mg
Description: Begacestat is a selective thiophene sulfonamide amyloid precursor protein gamma-secretase inhibitor (Abeta40,IC50=15 nM),and for the treatment of Alzheimer's disease. Target: Beta Amyloid. Smiles: OC[C@@H](NS(=O)(=O)c1ccc(Cl)s1)C(C(F)(F)F)C(F)(F)F. References: Mayer SC, et al. Discovery of begacestat, a...
| Keywords: | GSI-953 |
| Application: | Dementia therapeutic agent, gamma-Secretase inhibitor |
| CAS | 769169-27-9 |
| MW: | 391.74 D |
94.00€
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