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Item number: Cay41828-1

Norastemizole is a histamine H1 receptor antagonist (IC50 = 4.1 nM) and an active metabolite of the histamine H1 receptor antagonist and ether-a-go-go (ERG) channel blocker astemizole (Cay-16967). It is formed from astemizole by the cytochrome P450 (CYP) isoform 3A4 (CYP3A4). Norastemizole also inhibits currents in...

Keywords:	Tecastemizole, 1-[(4-fluorophenyl)methyl]-N-4-piperidinyl-1H-benzimidazol-2-amine
Application:	Astemizole active metabolite, histamine H1 receptor antagonist
CAS	75970-99-9
MW:	324.4 D

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Tecastemizole

Item number: TGM-T26253-100mg

Description: Tecastemizole (R 43512) is a selective antagonist of H1 receptor and a major metabolite of astemizole with anti-inflammatory effects. Target: Histamine Receptor. Smiles: Fc1ccc(Cn2c(NC3CCNCC3)nc3ccccc23)cc1. References: Lever R, et al. Effect of tecastemizole on pulmonary and cutaneous allergic...

Keywords:	R-43512, R43512, R 43512, T 1348, Norastemizole
Application:	Targets histamine receptor H1 (HRH1)
CAS	75970-99-9
MW:	324.4 D

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