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Item number: Cay14860-25

Leflunomide is a synthetic isoxazol and a prodrug form of A-771726 (Cay-14404), a dihydroorotate dehydrogenase inhibitor. Leflunomide inhibits de novo pyrimidine synthesis to regulate T lymphocyte progression through the cell cycle. It inhibits proliferation and activation of T cells when used at concentrations of...

Keywords:	Arava, HW 486, SU 101, 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Application:	Immunosuppressant, Pyrimidine synthesis inhibitor, Dihydroorotate dehydrogenase inhibitor
CAS	75706-12-6
MW:	270.2 D

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Leflunomide

Item number: LKT-L1817.1

Leflunomide is a pyrimidine biosynthesis inhibitor. It is an established disease-modifying antirheumatic drug. It has been approved for treatment of rheumatoid arthritis (RA) and may also be useful in treating patients with Felty´s syndrome. It is suggested that supression of TNF signalling is one of the...

Keywords:	HWA-486
Application:	Pyrimidine biosynthesis inhibitor
CAS	75706-12-6
MW:	270,21 D

From 135.00€ *

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