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Debromohymenialdisine
Item number: AG-CN2-0068-C100
Protein kinase C (PKC) inhibitor. Inhibits the ATP binding site. Cytotoxic and insecticidal. G2 DNA damage checkpoint inhibitor. Check point kinases 1 (Chk1) and 2 (Chk2) inhibitor. Does not inhibit ataxia-telangiectasia mutated (ATM) or ATM-Rad3-related proteins. MAP kinase kinase 1 (MEK-1) inhibitor....
| Keywords: | DBH, DBHA-SKF, SKF 108753 |
| Application: | PKC Inhibitor |
| Host: | Axinella carteri |
| CAS | 75593-17-8 |
| MW: | 245,2 D |
176.00€
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Debromohymenialdisine
Item number: Cay14873-100
Damaged DNA in humans is detected by sensor proteins that transmit a signal through checkpoint kinases (Chks) Chk1 and Chk2. Debromohymenialdisine (DBH) is a marine sponge alkaloid that inhibits Chk1 and Chk2 (IC50 = 3 and 3.5 µM, respectively), blocking G2 arrest. Because it does not significantly affect the...
| Keywords: | DBH, SKF 108753, (4Z)-4-(2-amino-1,5-dihydro-5-oxo-4H-imidazol-4-ylidene)-4,5,6,7-tetrahydro-pyrrolo[2,3-c]azepin-8(1H)-one |
| Application: | Chk1 / Chk2 inhibitor |
| CAS | 75593-17-8 |
| MW: | 245.2 D |
169.00€
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