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Item number: Cay14859-1

NSC 405020 binds to the hemopexin (PEX) domain of the membrane type-1 matrix metalloproteinase (MT1-MMP/MMP-14). It disrupts MT1-MMP homodimerization without affecting its catalytic activity in an assay using the MT1-MMP CAT domain, which is involved in its tumor promoting function (IC50 > 100 µM). In a mouse tumor...

Keywords:	3,4-dichloro-N-(1-methylbutyl)-benzamide
Application:	MT1-MMP inhibitor
CAS	7497-07-6
MW:	260.2 D

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