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CHF5074
Item number: Cay27917-1
CHF5074 is a modulator of gamma-secretase and a derivative of flurbiprofen (Cay-70250). It inhibits the secretion of amyloid beta (1-42) (Abeta42) in H4-APP695NL human neuroglioma cells that overexpress a mutated form of amyloid precursor protein (APP, IC50 = 41 µM) and selectively inhibits secretion of Abeta42 over...
| Keywords: | CS 1103, CSP1103, Itanapraced, 1-(3',4'-dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid |
| Application: | gamma-secretase modulator |
| CAS | 749269-83-8 |
| MW: | 325.2 D |
From 56.00€
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Itanapraced
Item number: TGM-T2262-100mg
Description: Itanapraced (CHF5074), a gamma-secretase modulator, reduces Abeta42/40 secretion (IC50: 3.6/18.4 µM). Target: Gamma-secretase, Beta Amyloid, Apoptosis. Smiles: OC(=O)C1(CC1)c1ccc(c(F)c1)-c1ccc(Cl)c(Cl)c1
| Keywords: | CHF5074 , CSP-1103 |
| Application: | gamma-secretase modulator |
| CAS | 749269-83-8 |
| MW: | 325.16 D |
From 41.00€
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