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K858 (Racemic)
Item number: TGM-T3120-100mg
Description: K858 Racemic (K858) is a selective mitotic kinesin Eg5 inhibitor which acts in an ATP-noncompetitive manner. Target: Apoptosis, Kinesin. Smiles: CC(=O)NC1=NN(C(C)=O)C(C)(S1)c1ccccc1. References: Nakai R, et al. Y Res. 2009 May 1,69(9):3901-9.
| Keywords: | K858, K858 Racemic |
| Application: | KIF11 inhibitor |
| CAS | 72926-24-0 |
| MW: | 277.34 D |
From 40.00€
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K858
Item number: Cay22112-1
K858 is an inhibitor of kinesin spindle protein Eg5 (IC50 = 1.3 µM for Eg5 ATPase activity). It inhibits growth (GI50 = 0.98 µM), induces mitotic arrest (EC50 = 1.6 µM), and activates caspase-3 (EC50 = 1.6 µM) in HCT116 cells. It selectively induces mitotic cell death in HCT116 cells over non-cancerous ARPE-19...
| Keywords: | N-(4-acetyl-4,5-dihydro-5-methyl-5-phenyl-1,3,4-thiadiazol-2-yl)-acetamide |
| Application: | KIF11 inhibitor |
| CAS | 72926-24-0 |
| MW: | 277.3 D |
From 44.00€
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