Description: Biotin-C5-NHS Ester is an alkyl/ether-based linker used in PROTAC synthesis [1]. Target: Others. Smiles: C(CCCC(NCCCCCC(ON1C(=O)CCC1=O)=O)=O)[C@H]2[C@@]3([C@](CS2)(NC(=O)N3)[H])[H]. References: An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted...

N-Hydroxysuccinimide (NHS) activates carboxylic acid groups (on biotin) to facilitate coupling reactions. Biotin-X-NHS is a compound used to attach biotin to primary amines under alkaline conditions (pH~8-9). For example, lysines on the surface of proteins, including antibodies, are ideal targets for biotinylation...

This biotin has a spacer arm of 22 A that reduces steric hindrance when binding several biotinylated molecules to one avidin complex, This reagent penetrates cell membranes because there is no charged group.

Biotin-X-NHS is an amino-reactive biotinylation reagent with a long spacer arm. The 6-aminocaproic acid spacer arm provides distance between the biotin and the target ligand which helps alleviate steric hindrance. Biotin-X-NHS is used to biotinylate antibodies, proteins, peptides, or amino acids by reacting with...