Borrelidin is a secondary metabolite produced by Streptomyces and other bacteria. It displays potent antiangiogenic activity, preventing tube formation in rat aorta explants (IC50 = 0.8 nM) and inducing apoptosis in endothelial cells. Borrelidin also alters the splicing of VEGF mRNA, producing an antiangiogenic...

Borrelidin is a macrolide antibiotic produced by Streptomyces. Borrelidin exhibits anti-parasitic, antifungal, anticancer, and anti-angiogenic activities. This compound inhibits threonyl-tRNA synthetase/ligase, inhibiting growth and survival of Trypanosoma, Plasmodium, and Phytophthora. In acute lymphocytic leukemia...

Macrolide antibiotic, Bacterial and eukaryal threonyl-tRNA synthetase (THrRS) inhibitor, Antiangiogenic (IC50 = 0.8 nM), Induces the collapse of formed capillary tubes in a dose-dependent fashion, In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of...

Description: Borrelidin (Treponemycin) is a macrolide antibiotic isolated from *Streptomyces rochei*, acting as a threonyl-tRNA synthetase inhibitor in both bacterial and eukaryal systems. Target: Others. Smiles: CC1CC(C)CC(C)C(O)C(=CC=CCC(OC(=O)CC(O)C(C)C1)C1CCCC1C(O)=O)C#N. References: Habibi D, et al. Borrelidin,...