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PF-431396
Item number: Cay17665-1
Proline-rich tyrosine kinase 2 (PYK2) and focal adhesion kinase (FAK) are nonreceptor tyrosine kinases that constitute the focal adhesion kinase subfamily. PYK2 is expressed in both bone-forming osteoblasts and bone-resorbing osteoclasts where it has a positive role in osteoclast maturation and bone resorption....
| Keywords: | N-[2-[[[2-[(2,3-dihydro-2-oxo-1H-indol-5-yl)amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]methyl]phenyl]-N-methyl-methane... |
| Application: | FAK / PYK2 inhibitor |
| CAS | 717906-29-1 |
| MW: | 506.5 D |
From 51.00€
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PF-431396
Item number: TGM-T2314-100mg
Description: PF-431396 is a dual PYK2/FAK inhibitor (IC50: 11/2 nM). Target: FAK, PYK2. Smiles: CN(c1ccccc1CNc1nc(Nc2ccc3NC(=O)Cc3c2)ncc1C(F)(F)F)S(C)(=O)=O. References: Han S, et al. J Biol Chem. 2009, 284(19), 13193-13201.
| CAS | 717906-29-1 |
| MW: | 506.5 D |
From 48.00€
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