Colorless to white adhered film. Soluble in DMSO or ethanol. Mycotoxin, Alkaloid antibiotic, Bacterial enoyl-acyl carrier protein reductase (FabI) inhibitor, Antineoplastic activity, Moderate cytotoxicity against A-549 and HL-60 cell lines. Induces cell cycle arrest through G2/M phase, presumably by inhibiting...

Meleagrin is an antibiotic derived from a deep ocean, penicillin-producing P. chrysogenum. It is produced as an end product in the roquefortine branched biosynthetic pathway. Meleagrin has been identified as an inhibitor of the bacterial enoyl-acyl carrier protein reductase (FabI) with IC50 values of 40.1 and 33.2...

Description: Meleagrin, a roquefortine C-derived alkaloid produced by Penicillium fungi, serves as both a class of FabI inhibitors and a lead c-Met inhibitory entity for controlling c-Met-dependent metastatic and invasive breast malignancies. It exhibits antimicrobial and anti-proliferative activities. Target:...