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NSC 319726
Item number: Cay23701-5
NSC 319726 is a reactivator of p53R175, a p53 conformational mutant that cannot bind DNA. It selectively inhibits growth of human tumor cell lines containing mutant p53 over those containing wild-type p53 (IC50s = 0.1-1 and >10 µM, respectively). NSC 319726 induces apoptosis in TOV112D (p53R175H), but not OVCAR3...
| Keywords: | 2-[1-(2-pyridinyl)ethylidene]hydrazide, 1-azetidinecarbothioic acid |
| Application: | p53-R175 reactivator |
| CAS | 71555-25-4 |
| MW: | 234.3 D |
From 145.00€
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ZMC1
Item number: TGM-T2464-100mg
Description: NSC-319726 (ZMC1), a mutant p53R175 reactivator, suppresses growth of fibroblasts that expresses the p53R175 mutation (IC50 = 8 nM). Target: p53. Smiles: C\C(=N/NC(=S)N1CCC1)c1ccccn1. References: Yu X, et al. Cancer Cell, 2012, 21(5), 614-625.
| Application: | p53-R175 reactivator |
| CAS | 71555-25-4 |
| MW: | 234.32 D |
From 31.00€
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