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Item number: Cay24190-10

Plinabulin is a diketopiperazine that induces complete tubulin depolymerization in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 2 µM. It induces HUVEC monolayer permeability, a marker of vascular collapse, in vitro. Plinabulin is cytotoxic against a panel of cancer cell lines,...

Keywords:	NPI-2358, 3Z-[[5-(1,1-dimethylethyl)-1H-imidazol-4-yl]methylene]-6Z-(phenylmethylene)-2,5-piperazinedione
Application:	Tubulin depolymerizing agent, antineoplastic
CAS	714272-27-2
MW:	336.4 D

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Plinabulin

Item number: TGM-T2511-100mg

Description: Plinabulin (NPI-2358) (NPI-2358) is a vascular disrupting agent (VDA) against tubulin-depolymerizing tumor cells ( IC50: 9.8-18 nM). Plinabulin selectively targets and binds to the colchicine-binding site of tubulin, thereby interrupting equilibrium of microtubule dynamics. This disrupts mitotic spindle...

Keywords:	NPI-2358
Application:	Antineoplastic
CAS	714272-27-2
MW:	336.39 D

From 32.00€ *

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