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Item number: Cay15312-1

LY2157299 is a small molecule inhibitor of the TGF-beta receptor type 1 kinase (IC50 = 56 nM). It has been used to study the role of TGF-beta signaling in chemotherapy-induced expansion of cancer stem-like cells in triple negative breast cancer cell lines and xenografts. LY2157299 has also been shown to inhibit the...

Keywords:	Galunisertib, 4-[5,6-dihydro-2-(6-methyl-2-pyridinyl)-4H-pyrrolo[1,2-b]pyrazol-3-yl]-6-quinolinecarboxamide
Application:	TGFBR1 inhibitor
CAS	700874-72-2
MW:	369.4 D

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Galunisertib

Item number: TGM-T2510-25mg

Description: Galunisertib (LY2157299) is a TGF-beta receptor type I (TGF-betaRI) inhibitor (IC50=56 nM) that is selective. Galunisertib has antitumor activity and can be used in combination with PD-1 inhibitors. Target: TGF-beta/Smad. Smiles: Cc1cccc(n1)-c1nn2CCCc2c1-c1ccnc2ccc(cc12)C(N)=O. References: Cong L, et...

Keywords:	LY2157299
Application:	Targets TGF-beta receptor type-1 [EC:2.7.11.30] (TGFBR1, ALK5)
CAS	700874-72-2
MW:	369.42 D

From 39.00€ *

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