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Item number: Cay11793-1

SB-505124 inhibits the TGF-beta1 receptor serine/threonine kinase ALK5 with an IC50 value of 47 nM. Though it is a less potent antagonist of ALK4 (IC50 = 129 nM) and ALK7, SB-505124 selectively and concentration-dependently inhibits ALK4-, ALK5-, and ALK7-dependent activation of downstream SMAD2 and SMAD3 and...

Keywords:	2-[4-(1,3-benzodioxol-5-yl)-2-(1,1-dimethylethyl)-1H-imidazol-5-yl]-6-methyl-pyridine
Application:	ALK5 inhibitor
CAS	694433-59-5
MW:	335.4 D

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SB-505124

Item number: TGM-T2462-100mg

Description: SB505124 is a selective inhibitor of TGFbetaR for ALK4, ALK5. Target: TGF-beta/Smad, ALK. Smiles: Cc1cccc(n1)-c1[nH]c(nc1-c1ccc2OCOc2c1)C(C)(C)C. References: DaCosta Byfield S, et al. Mol Pharmacol. 2004, 65(3), 744-752.

Application:	ALK5 inhibitor
CAS	694433-59-5
MW:	335.4 D

From 33.00€ *

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