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(-)-Nutlin-3
Item number: Cay18585-1
(-)-Nutlin-3 is an inhibitor of the protein-protein interaction between p53 and Mdm2 (IC50 = 0.09 µM). It increases p53 levels, induces apoptosis, and reduces cell viability in HCT116, SJSA-1, and RKO cells that express wild-type p53 but not MDA-MB-435 or SW480 cells expressing mutant p53. (-)-Nutlin-3 (200 mg/kg)...
| Keywords: | Nutlin 3a,... |
| Application: | Mdm2-p53 binding inhibitor |
| CAS | 675576-98-4 |
| MW: | 581.5 D |
From 128.00€
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Nutlin-3a
Item number: TGM-T6023-1mg
Description: Nutlin-3a ((-)-Nutlin-3), the active enantiomer of Nutlin-3, inhibits MDM2-p53 interactions and stabilizes the p53 protein. Target: Autophagy, Apoptosis, E1/E2/E3 Enzyme. Smiles: COc1ccc(C2=N[C@H]([C@H](N2C(=O)N2CCNC(=O)C2)c2ccc(Cl)cc2)c2ccc(Cl)cc2)c(OC(C)C)c1. References: Tovar C, et al. Proc Natl...
| Keywords: | Nutlin-3a chiral, (-)-Nutlin-3, (-)-Nutlin-3 |
| Application: | Mdm2-p53 binding inhibitor |
| CAS | 675576-98-4 |
| MW: | 581.49 D |
From 45.00€
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