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Nintedanib esylate
Item number: TGM-T5001-100mg
Description: Nintedanib esylate (BIBF 1120 esylate) is a potent triple angiokinase inhibitor targeting VEGFR1/2/3, FGFR1/2/3, and PDGFRalpha/beta. Target: PDGFR, FGFR, VEGFR. Smiles: CCS(O)(=O)=O.COC(=O)c1ccc2c(NC(=O)\C2=C(/Nc2ccc(cc2)N(C)C(=O)CN2CCN(C)CC2)c2ccccc2)c1. References: Roth GJ, et al. Design,...
| Keywords: | BIBF 1120 (esylate), Intedanib, Nintedanib Ethanesulfonate Salt, BIBF 1120 |
| Application: | Targets FMS-like tyrosine kinase 1 [EC:2.7.10.1] (FLT1, VEGFR1) |
| CAS | 656247-18-6 |
| MW: | 649.76 D |
From 37.00€
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BIBF 1120 (esylate)
Item number: Cay31082-50
BIBF 1120 is an inhibitor of the receptor tyrosine kinases VEGFR, FGFR, and PDGFR (IC50s = 13-34, 37-610, 59, and 65 nM for VEGFR1-3, FGFR1-4, PDGFRalpha, and PDGFRbeta, respectively). It is selective for VEGFR, FGFR, and PDGFR over a panel of 33 kinases but does inhibit FLT3, LCK, LYN, and Src (IC50s = 16-156 nM)....
| Keywords: | Nintedanib,... |
| Application: | VEGFR / FGFR / PDGFR inhibitor |
| CAS | 656247-18-6 |
| MW: | 649.8 D |
From 67.00€
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