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Item number: Cay13252-50

(-)-Sitagliptin is a potent inhibitor of dipeptidyl peptidase 4 (DPP-4, IC50 = 18 nM). It is selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases, including DPP-9, DPP-2, and amino peptidase P. (-)-Sitagliptin improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet...

Keywords:	(R)-Sitagliptin, INN, MK-431, ONO-5435,...
Application:	DPP4 inhibitor
CAS	654671-78-0
MW:	505.3 D

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