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Item number: TGM-T14778-100mg

Description: BRD6989 is an analog of the natural product cortistatin A (dCA). Which inhibits CDK8 and upregulates IL-10. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. Target: IL Receptor, CDK, Interleukin. Smiles:...

Application:	Cdk8/cyclin C complex inhibitor
CAS	642008-81-9
MW:	264.33 D

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BRD6989

Item number: Cay35358-10

BRD6989 is an inhibitor of the Cdk8/cyclin C complex. It selectively binds to the Cdk8/cyclin C complex (IC50 = ~200 nM) over the Cdk1/cyclin B, Cdk2/cyclin A, Cdk5/p35, Cdk7/cyclin H, and Cdk9/cyclin T complexes at 1,000 nM. BRD6989 increases the production of IL-10 in primary mouse bone marrow-derived dendritic...

Keywords:	2-amino-5,6,7,8-tetrahydro-6-methyl-4-(3-pyridinyl)-3-quinolinecarbonitrile
Application:	Cdk8/cyclin C complex inhibitor
CAS	642008-81-9
MW:	264.3 D

From 124.00€ *

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