Chartreusin is an antibiotic originally isolated from S. chartreusis with diverse biological activities. It inhibits growth of S. aureus, B. subtilis, M. luteus, M. flavus, B. fragilis, C. difficile, C. perfringens, and P. acnes (MICs = 0.4-12.5 µg/ml). Chartreusin binds to DNA and induces electrophoretic shifts in...

An antitumor antibiotic from Streptomyces chartreusis. It inhibits topoisomerase II, and has been shown to inhibit DNA and RNA synthesis in certain models.

Antibiotic, Antitumor compound, Topoisomerase II inhibitor, Induces single-strand scission in DNA in the presence of reducing agents. Isolated from Streptomyces chartreusis.

Chartreusin is an antitumor antibiotic that binds to GC-rich tracts in DNA, with a clear preference for B-DNA over Z-DNA. It inhibits RNA synthesis and causes single-strand scission of DNA via the formation of free radicals. Chartreusin is also potent inhibitor of topoisomerase II. , , DMSO and DMF, partially...