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Item number: Cay43929-10

TP-003 is a positive allosteric modulator of the GABAA receptor (GABAAR). It potentiates GABA-induced currents in HEK293 cells expressing alpha1beta2gamma2, alpha2beta3gamma2, alpha3beta3gamma2, or alpha5beta2gamma2 subunit-containing GABAARs (EC50s = 20. 10. 3. and 5. nM, respectively). TP-003 (10 mg/kg) increases...

Keywords:	2',4-difluoro-5'-[8-fluoro-7-(1-hydroxy-1-methylethyl)imidazo[1,2-a]pyridin-3-yl]-1,1'-biphenyl]-2-carbonitrile
Application:	Positive allosteric GABA(A) receptor modulator
CAS	628690-75-5
MW:	407.4 D

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