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Item number: TGM-T2109-100mg

Description: SD-208 (ALK5 Inhibitor V), a selective TGF-betaRI (ALK5) inhibitor (IC50: 48 nM), is >100-fold selectivity over TGF-betaRII. Target: TGF-beta/Smad. Smiles: Fc1ccc(Cl)cc1-c1nc(Nc2ccncc2)c2nccnc2n1. References: Uhl M, et al. Cancer Res. 2004, 64(21), 7954-7961.

Keywords:	ALK5 Inhibitor V, SD208
Application:	TGFBR1 inhibitor
CAS	627536-09-8
MW:	352.75 D

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SD 208

Item number: Cay16619-10

TGF-beta is a cell growth and differentiation factor that has roles in cancer, fibrosis, and numerous other pathologies. TGF-beta signals through two receptor tyrosine kinases, TGF-betaRI and TGF-betaRII. SD 208 is a potent inhibitor of TGF-betaRI kinase (EC50 = 48 nM) that has minimal or no effect at a variety of...

Keywords:	TGF-beta RI Kinase Inhibitor V, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-4-pteridinamine
Application:	TGFBR1 inhibitor
CAS	627536-09-8
MW:	352.8 D

From 52.00€ *

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