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Item number: TGM-T6153-100mg

Description: Icotinib (Conmana) is an orally available quinazoline-based inhibitor of epidermal growth factor receptor (EGFR), with potential antineoplastic activity. Target: EGFR. Smiles: C#Cc1cccc(Nc2ncnc3cc4OCCOCCOCCOc4cc23)c1. References: Tan F, et al. Lung Cancer, 2012, 76(2), 177-182.

Keywords:	BPI-2009, Conmana, BPI-2009H
Application:	Targets epidermal growth factor receptor [EC:2.7.10.1] (EGFR, ERBB1)
CAS	610798-31-7
MW:	391.42 D

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Icotinib

Item number: Cay30093-1

Icotinib is an inhibitor of EGFR (IC50 = 2 nM). It is selective for EGFR over Abl, Abl2, and c-Src tyrosine kinases at 1,000 nM. Icotinib inhibits EGFR-mediated tyrosine phosphorylation in A431 human epidermoid carcinoma cells with an IC50 value of 45 nM. It inhibits the growth of PC-9 and HCC827 non-small cell lung...

Keywords:	BPI 2009H, N-(3-ethynylphenyl)-7,8,10,11,13,14-hexahydro-[1,4,7,10]tetraoxacyclododecino[2,3-g]quinazolin-4-amine
Application:	EGFR inhibitor
CAS	610798-31-7
MW:	391.4 D

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