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SB-772077B dihydrochloride
Item number: TGM-T16855-100mg
Description: SB-772077B dihydrochloride is an aminofurazan-based Rho kinase inhibitor with IC50 values of 5.6 nM for ROCK1 and 6 nM for ROCK2. Target: ROCK. Smiles: Cl.Cl.CCn1c(nc2cncc(C(=O)N3CC[C@H](N)C3)c12)-c1nonc1N. References: Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory...
| Application: | ROCK inhibitor |
| CAS | 607373-46-6 |
| MW: | 415.28 D |
From 94.00€
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SB-772077B (hydrochloride)
Item number: Cay30975-1
SB-772077B is a Rho-associated kinase (ROCK) inhibitor (IC50s = 5.6 and 6 nM for ROCK1 and ROCK2, respectively). It is selective for ROCK1 and ROCK2 over Akt1, Akt2, and Akt3 (IC50s = 324, 1,950, and 1,290 nM, respectively), as well as Cdk2, GSK3alpha, IKKbeta, JNK3, and Plk (IC50s = >7,000 nM for all), but also...
| Keywords: | [2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-1H-imidazo[4,5-c]pyridin-7-yl][(3S)-3-amino-1-pyrrolidinyl]-methanone,... |
| Application: | ROCK inhibitor |
| CAS | 607373-46-6 |
| MW: | 415.3 D |
From 78.00€
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