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Item number: Cay16472-10

Pyrimethamine is an antiprotozoal agent that is primarily active against P. falciparum, inhibiting the protozoal enzyme dihydrofolate reductase (DHFR). By blocking DHFR activity, pyrimethamine prevents the production of tetrahydrofolic acid, an essential coenzyme involved in DNA and RNA synthesis. In in vivo...

Keywords:	Darapram, Daraprim(R), Khloridin, NSC 3061, 5,4-chlorophenyl-6-ethyl-2,4-pyrimidinediamine
Application:	Protozoal dihydrofolate reductase (DHFR) inhibitor
CAS	58-14-0
MW:	248.7 D

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Pyrimethamine

Item number: TGM-T0849-50mg

Description: Pyrimethamine (Pirimecidan) is a competitive inhibitor of dihydrofolate reductase (DHFR), used as an antimalarial drug. Target: DHFR, Parasite, Antifolate. Smiles: C(C)C=1C(=C(N)N=C(N)N1)C2=CC=C(Cl)C=C2. References: Maegawa GH, et al. J Biol Chem, 2007, 282(12), 9150-9161.

Keywords:	Pirimetamin, RP 4753, Pirimecidan
CAS	58-14-0
MW:	248.71 D

From 37.00€ *

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