3 products were found matching "579515-63-2"!
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GW-806742X
Item number: SYN-1215-M001
Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...
| Keywords: | GW806742X, AC1NS7PT, AGN-PC-0LQ49Y |
| Application: | VEGFR2 inhibitor |
| CAS | 579515-63-2 |
| MW: | 573,6 D |
From 139.00€
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GW 806742X
Item number: Cay37541-10
GW 806742X is an inhibitor of necroptosis. It binds to mixed lineage kinase domain-like protein (Mlkl, Kd = 9.3 µM for the mouse protein), reducing its association with the cytoplasmic membrane, and decreases necroptosis induced by TNF-alpha, a Smac mimetic, and the caspase inhibitor Q-VD-OPH (Cay-15260) in isolated...
| Keywords: | 3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide |
| Application: | Necroptosis inhibitor |
| CAS | 579515-63-2 |
| MW: | 573.5 D |
From 83.00€
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GW806742X
Item number: TGM-T11520-100mg
Description: GW806742X is an inhibitor of Mixed Lineage Kinase Domain-Like protein (MLKL) which binds the MLKL pseudokinase domain (Kd: 9.3 µM) with anti-necroptosis activity. GW806742X has activity against VEGFR2. Target: VEGFR, MLK. Smiles: CN(c1ccc(NC(=O)Nc2ccc(OC(F)(F)F)cc2)cc1)c1ccnc(Nc2cccc(c2)S(N)(=O)=O)n1....
| CAS | 579515-63-2 |
| MW: | 573.55 D |
From 30.00€
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