2 products were found matching "579515-63-2"!

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Item number: Cay37541-10

GW 806742X is an inhibitor of necroptosis. It binds to mixed lineage kinase domain-like protein (Mlkl, Kd = 9.3 µM for the mouse protein), reducing its association with the cytoplasmic membrane, and decreases necroptosis induced by TNF-alpha, a Smac mimetic, and the caspase inhibitor Q-VD-OPH (Cay-15260) in isolated...

Keywords:	3-[[4-[methyl[4-[[[[4-(trifluoromethoxy)phenyl]amino]carbonyl]amino]phenyl]amino]-2-pyrimidinyl]amino]-benzenesulfonamide
Application:	Necroptosis inhibitor
CAS	579515-63-2
MW:	573.5 D

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GW-806742X

Item number: SYN-1215-M001

Soluble in DMSO. Potent protein kinase VEGFR2 inhibitor (2nm range). Binds to the pseudokinase domain of MLKL and blocks cell death by necroptosis, as well. With regards to its role in necroptosis, it is an ATP-mimetic that was shown to bind recombinant mouse MLKL pseudokinase domain, which showed inhibited...

Keywords:	GW806742X, AC1NS7PT, AGN-PC-0LQ49Y
Application:	VEGFR2 inhibitor
CAS	579515-63-2
MW:	573,6 D

From 119.00€ *

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