Description: Clozapine (HF 1854) is a tricylic dibenzodiazepine, classified as an atypical antipsychotic agent. It binds several types of central nervous system receptors, and displays a unique pharmacological profile. Clozapine is a serotonin antagonist, with strong binding to 5-HT 2A/2C receptor subtype. It also...

Clozapine is a partial agonist at the serotonin (5-HT) receptor subtype 5-HT1A (Ki = 180 nM). It also binds to the 5-HT2A, 5-HT2C, 5-HT3, 5-HT6 and 5-HT7 receptors (Kis = 3.3, 13, 110, 4, and 21 nM, respectively), as well as the histamine H1 and alpha1-adrenergic receptors (Kis = 2.1 and 23 nM, respectively). It...

Antipsychotic drug. It is effective in the treatment of levodopa-induced dyskinesias in severe Parkinsons disease, and increases both acetylcholine and dopamine release in rat ventral hippocampus.

Clozapine (Cay-30674) is an analytical reference material categorized as an atypical antipsychotic. This product is intended for analytical forensic applications. This product is also available as a general research tool (Cay-12059, Cay-25779).Formal Name:...

Clozapine (CRM) (Cay-31084) is a certified reference material categorized as an atypical antipsychotic. This product is intended for analytical forensic applications. This product is also available as a general research tool (Cay-12059, Cay-25779).CAS Number: 5786-21-0. Molecular Formula: C18H19ClN4. Formula Weight:...