Description: Domperidone (R33812)(Motilium) is a dopamine blocker and an antidopaminergic reagent. It blocks the action of. It has strong affinities for the D2 and D3 dopamine receptors, which are found in the chemoreceptor trigger zone, located just outside the blood brain barrier, which - among others - regulates...

Domperidone is a dopamine D2 receptor antagonist (Ki = 0.3 nM in CHO cells expressing the rat receptor). It is selective for dopamine D2 over D3 receptors (Ki = 9.5 nM). Domperidone (0.5-5 µg/kg) inhibits dipropyl dopamine-induced femoral vasodilation in dogs, indicating dopamine D2 receptor antagonist activity, and...

A potent inotropic agent. Effective against interleukin 2 induced hypotension.

Domperidone is a peripheral dopamine D2-like receptor antagonist that does not readily cross the blood-brain barrier. It demonstrates a potent affinity for the rat D2 receptor and is also reported to inhibit the rat D3 receptor. The antidopaminergic effects are cross-realted to its gastroprokinetic and antiemetic...