Antibiotic, Active against Gram-positive and Gram-negative bacteria, yeast, filamentous fungi, protozoa and insects, Potent bacterial and yeast RNA polymerases inhibitor, Inhibitor of fungal mannan and glucan formation, Similar to thiolutin, Antitumor compound. Isolated from Streptomyces thioluteus.

Aureothricin is a dithiolopyrrolone antibiotic first isolated from Streptomyces sp. that exhibits broad-spectrum antimicrobial activity against many Gram-positive and Gram-negative bacteria, as well as strains of M. tuberculosis. It is also reported to inhibit tumor angiogenesis, blocking activity of the vitronectin...

Description: Aureothricin, a dithiolopyrrolone (DTP) antibiotic originally derived from Streptomyces, demonstrates a broad-spectrum of antibacterial effectiveness. Additionally, it inhibits the adhesion of human umbilical vein endothelial cells (HUVECs) to vitronectin[1]. Target: Antibacterial. Smiles:...

Aureothricin is an antibiotic first described by Umezawa and co-workers in Japan in 1949. Resurgent interest in this class of microbial metabolites was stimulated by the discovery of their selective antitumor activity. Aureothricin is a more hydrophobic analogue of thiolutin but has received only limited attention....